Grey's Anatomy is an American medical drama television series that premiered on March 27, 2005, on the American Broadcasting Company (ABC) as a mid-season replacement. The fictional series focuses on the lives of surgical interns, residents, and attending physicians, as they develop into seasoned doctors while trying to maintain personal lives and relationships. The title is a play on Gray's Anatomy, a classic human anatomy textbook first published in 1858 in London and written by Henry Gray. Shonda Rhimes developed the pilot and continues to write for the series; she is also one of the executive producers, along with Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding, and Allan Heinberg. Although the series is set in Seattle (at the fictional Seattle Grace Hospital, later known as the Grey-Sloan Memorial Hospital), it is filmed primarily in Los Angeles, California.
The series was designed to be racially diverse and used color-blind casting. It revolves around the title character, Dr. Meredith Grey, played by Ellen Pompeo, first featured as an intern. The original cast consisted of nine star-billed actors: Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T. R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington and Patrick Dempsey. The cast has undergone major changes through the series' run, with many members leaving and being replaced by others. In its fifteenth season, the show has a large ensemble of eleven actors, including four characters from the original cast (Meredith Grey, Alex Karev, Miranda Bailey, and Richard Webber).
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